The research of my group focuses on the development and establishment of theoretical methods in the field of computational biology and biophysics. Mathematically, I am active the fields of stochastic analysis and graph theory. About 50% of our efforts focus on the development of new simulation and analysis methods that are practical and useful to deal with the intricacies of complex biological systems. The other 50% are dedicated to pushing large biological applications and to make an impact in the application fields of computational biology and biophysics.

Currently, the modeling of conformation dynamics of single molecules or small complexes is our major application area, combining both simulation and experimental data. In parallel, we are pursuing the development of improved simulation techniques for molecular dynamics which aim at circumventing the famous sampling problem, i.e., the fact that simulations at great detail can, in practice, not be carried out on biological timescales. In parallel, we are building up the research area cellular molecular dynamics which aims at conducting explicit structural and time-resolved models for the interactions of biomolecules at a cellular level. This will, in the long term, contribute to the evolution of a structural system biology.